产品名称

英文名称：Enzalutamide

同义词

Enzalutamide、915087-33-1、MDV3100、4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide、MDV-3100、Enzalutamide (MDV3100)、MDV 3100、XTANDI、MDV3100 (Enzalutamide)、UNII-93T0T9GKNU、93T0T9GKNU、CHEBI6853、MDV3100、恩扎鲁胺、4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫酮-1-咪唑烷基]-2-氟-N-甲基苯甲酰胺、恩杂鲁胺

产品性质

CAS编号：915087-33-1

分子式：C21H16F4N4O2S

分子量：464.44

EC号：805-022-1

PubChem编号：15951529

别名：MDV3100|恩扎鲁胺|4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫酮-1-咪唑烷基]-2-氟-N-甲基苯甲酰胺|恩杂鲁胺

英文别名：Enzalutamide|915087-33-1|MDV3100|4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide|MDV-3100|Enzalutamide (MDV3100)|MDV 3100|XTANDI|MDV3100 (Enzalutamide)|UNII-93T0T9GKNU|93T0T9GKNU|CHEBI6853

规格或纯度：≥98%

英文名称：Enzalutamide

生化机理：MDV3100 is an androgen receptor inhibitor and antagonizes induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2) in combination with the synthetic androgen R1881 in parental LNCaP cells. MDV3100 prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Enzalutamide (MDV3100)是一种雄激素受体(AR)拮抗剂，IC50为36 nM。An androgen receptor inhibitorEnzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM.An androgen receptor inhibitor

ALogP：3.6

IUPAC Name：4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N-methylbenzamide

INCHI：InChI=1S/C21H16F4N4O2S/c1-20(2)18(31)28(12-5-4-11(10-26)15(8-12)21(23,24)25)19(32)29(20)13-6-7-14(16(22)9-13)17(30)27-3/h4-9H,1-3H3,(H,27,30)

InChi Key：WXCXUHSOUPDCQV-UHFFFAOYSA-N

Canonical SMILES：CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C

Isomeric SMILES：CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C

关联CAS：915087-33-1

PubChem CID：15951529

MeSH Entry Terms：4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-(methyl-d3)benzamide;4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-benzamide;enzalutamide;enzaluta

DrugBank Ligand：DB08899

CAS Registry No.：915087-33-1

ChEMBL Ligand：CHEMBL1082407

Wikipedia：Enzalutamide

PEP：enzalutamide

DrugCentral Ligand：4628

溶解性：DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥15mg/mL

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn childH360D May damage the unborn child

预防措施声明：P273,P280,P405,P501,P264,P260,P270,P391,P330,P203,P301+P317,P318,P319

产品包装