产品名称

英文名称：AMG-458

同义词

AMG-458、913376-83-7、AMG458、AMG 458、1-(2-Hydroxy-2-methylpropyl)-N-(5-((7-methoxyquinolin-4-yl)oxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide、4535RW5Y3A、1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yl)oxypyridin-2

产品性质

CAS编号：913376-83-7

分子式：C30H29N5O5

分子量：539.58

PubChem编号：24764449

英文别名：AMG-458|913376-83-7|AMG458|AMG 458|1-(2-Hydroxy-2-methylpropyl)-N-(5-((7-methoxyquinolin-4-yl)oxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide|4535RW5Y3A|1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yl)oxypyridin-2

规格或纯度：≥99%

英文名称：AMG-458

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍AMG-458 是有效的、选择性的 的 c-Met 抑制剂，其对人和小鼠的 Ki 值分别为 1.2 nM 和 2.0 nM。Product DescribtionAMG-458 is a potent, selective and orally bioavailable c-Met inhibitor, with Ki values of 1.2 nM and 2.0 nM for human and mouse c-Met, respectively.

PubChem SID：488200680

IUPAC Name：1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yl)oxypyridin-2-yl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide

INCHI：InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)

InChi Key：GLBZSOQDAOLMGC-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC

Isomeric SMILES：CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC

PubChem CID：24764449

溶解性：DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装