产品名称

英文名称：OSI-906 (Linsitinib)

同义词

Linsitinib、867160-71-2、OSI-906、Linsitinib(OSI-906)、OSI906、OSI 906、OSI-906AA、OSI-906 (Linsitinib)、ASP-7487、3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol、15A52GPT8T、CHEMBL1091644、MMV676605、cis-3-(8-amino-1-(2-phenyl、顺式-3-[8-氨基-1-(2-苯基-7-喹啉基)咪唑并[1,5-A]吡嗪-3-基]-1-甲基环丁醇

产品性质

CAS编号：867160-71-2

分子式：C26H23N5O

分子量：421.51

PubChem编号：11640390

别名：顺式-3-[8-氨基-1-(2-苯基-7-喹啉基)咪唑并[1,5-A]吡嗪-3-基]-1-甲基环丁醇

英文别名：Linsitinib|867160-71-2|OSI-906|Linsitinib(OSI-906)|OSI906|OSI 906|OSI-906AA|OSI-906 (Linsitinib)|ASP-7487|3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol|15A52GPT8T|CHEMBL1091644|MMV676605|cis-3-(8-amino-1-(2-phenyl

规格或纯度：≥99%

英文名称：OSI-906 (Linsitinib)

生化机理：Linsitinib is highly potent, orally efficacious and highly selective, dual ATP-competitive tyrosine kinase inhibitor of insulin-like growth factor-1 receptor (IGF-1R) (IC50 35 nM) and insulin receptor (IR) (IC50 75 nM).Potent and selective dual IGF-1R (IC 50 = 35 nM in cell-free assay) and Insulin Receptor (IC 50 = 75 nM in cell-free assay) kinase inhibitor. Inactive towards\xa0Abl, ALK, BTK, EGFR, FGFR1/2 and PKA. Displayed <50% inhibition at 1 μM against a panel of 88

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Linsitinib is a potent, selective insulin-like growth factor-1 receptor (IGF-1R, IC50 = 35 nM) and insulin receptor (IR, IC50 = 75 nM) kinase inhibitor which works to block the autophosphorylation of IGF-1R and IR. Additionally, in vitro studies of Linsitinib have demonstrated its ability to inhibit the proliferation of multiple tumor cell lines.Linsitinib is a selective inhibitor of IGF-1R with IC50 of 35 nM, and modestly potent to InsR with IC50 of 75 nM, and has no activity towards Abl, ALK, BTK, EGFR, FGFR1/2, PKA etc.Linsitinib is a potent, selective insulin-like growth factor-1 receptor (IGF-1R, IC50 = 35 nM) and insulin receptor (IR, IC50 = 75 nM) kinase inhibitor which works to block the autophosphorylation of IGF-1R and IR. Additionally, in vitro studies of Linsitinib have demonstrated its ability to inhibit the proliferation of multiple tumor cell lines.Linsitinib 是一种选择性的 IGF-1R 抑制剂，IC50 值为 35 nM，也适度地作用于 InsR，IC50 值为 75 nM；对 Abl，ALK，BTK，EGFR，FGFR1/2，PKA 等没有作用。

IUPAC Name：3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol

INCHI：InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)

InChi Key：PKCDDUHJAFVJJB-UHFFFAOYSA-N

Canonical SMILES：CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O

Isomeric SMILES：CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O

PubChem CID：11640390

CAS Registry No.：867160-71-2

ChEMBL Ligand：CHEMBL1091644

Wikipedia：Linsitinib

溶解性：DMSO 84 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装