产品名称

英文名称：BIIB021

同义词

BIIB021、848695-25-0、6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine、BIIB-021、CNF2024、BIIB 021、CNF-2024、UNII-851B9FQ7Q0、851B9FQ7Q0、CNF 2024、CHEMBL467399、CHEBI90687、6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-ami

产品性质

CAS编号：848695-25-0

分子式：C14H15ClN6O

分子量：318.77

PubChem编号：16736529

英文别名：BIIB021|848695-25-0|6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine|BIIB-021|CNF2024|BIIB 021|CNF-2024|UNII-851B9FQ7Q0|851B9FQ7Q0|CNF 2024|CHEMBL467399|CHEBI90687|6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-ami

规格或纯度：≥98%

英文名称：BIIB021

生化机理：Oral administration of BIIB021 leads to tumor growth inhibition in many tumor xenograft models including N87, BT474, CWR22, U87, SKOV3 and Panc-1. BIIB021 effectively inhibits growth of L540cy tumor at a dose of 120 mg/kg. BIIB021 significantly enhances antitumor growth effect of radiation in JHU12 xenograft.Selective, Hsp90 competitive inhibitor (K i = 1.7 nM).\xa0Displays no significant activity at a range of ATP-binding kinases or Na + K + ATPase.\xa0Induces degradation of HER-2 in vitro (EC 50 = 38 nM in MCF-7 cells).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：BIIB021(CNF2024)是口服活性的HSP90抑制剂，Ki和EC50分别为1.7 nM和38 nM。A selective large conductance calcium activated potassium channel activatorBIIB021 is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.A selective large conductance calcium activated potassium channel activator

ALogP：1.9

IUPAC Name：6-chloro-9-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]purin-2-amine

INCHI：InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)

InChi Key：QULDDKSCVCJTPV-UHFFFAOYSA-N

Canonical SMILES：CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N

Isomeric SMILES：CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N

PubChem CID：16736529

ChEMBL Ligand：CHEMBL467399

CAS Registry No.：848695-25-0

RCSB PDB Ligand：94M

溶解性：DMSO ≥60mg/mL Water <1.2mg/mL Ethanol ≥1.8mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装