产品名称

英文名称：VU 0361737

同义词

1161205-04-4、VU 0361737、VU0361737、N-(4-chloro-3-methoxyphenyl)picolinamide、N-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide、N-(4-CHLORO-3-METHOXYPHENYL)-2-PYRIDINECARBOXAMIDE、C13H11ClN2O2、CHEMBL562551、2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-

产品性质

CAS编号：1161205-04-4

分子式：C13H11ClN2O2

分子量：262.69

MDL号：MFCD16618402

PubChem编号：44191096

英文别名：1161205-04-4|VU 0361737|VU0361737|N-(4-chloro-3-methoxyphenyl)picolinamide|N-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide|N-(4-CHLORO-3-METHOXYPHENYL)-2-PYRIDINECARBOXAMIDE|C13H11ClN2O2|CHEMBL562551|2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-

规格或纯度：≥98%(HPLC)

英文名称：VU 0361737

生化机理：mGlu4受体的选择性正变构调节剂（人和大鼠受体的EC50值分别为240和110 nM）。在mGlu1，mGlu2，mGlu3，mGlu6和mGlu7受体上不活跃，在mGlu5和mGlu8受体上显示弱活性。脑渗透剂。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：VU 0361737是一种选择性mGlu4受体正变构调节剂 (PAM), 作用于人类和大鼠受体, EC50分别为240 nM和110 nM, 对mGlu5和mGlu8受体具有微弱的作用活性,a selective positive allosteric modulator at mGluR-4VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.a selective positive allosteric modulator at mGluR-4

IUPAC Name：N-(4-chloro-3-methoxyphenyl)pyridine-2-carboxamide

INCHI：InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)

InChi Key：ARYUXFNGXHNNDM-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl

Isomeric SMILES：COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl

WGK Germany：3

PubChem CID：44191096

CAS Registry No.：1161205-04-4

ChEMBL Ligand：CHEMBL562551

GPCRdb Ligand：VU0361737

溶解性：溶于DMSO, 最高浓度 (mg/mL) 26.27, 最高浓度(mM) 100

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowed

预防措施声明：P305+P351+P338

产品包装