产品名称

英文名称：PD-161570

同义词

192705-80-9、PD 161570、PD-161570、pd161570、N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea、CHEMBL45827、1-tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimi

产品性质

CAS编号：192705-80-9

分子式：C26H35Cl2N7O

分子量：532.51

MDL号：MFCD16618403

PubChem编号：5328135

英文别名：192705-80-9|PD 161570|PD-161570|pd161570|N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea|CHEMBL45827|1-tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimi

规格或纯度：≥98%(HPLC)

英文名称：PD-161570

生化机理：选择性FGFR抑制剂（FGFR，PDGFR和EGFR的IC50值分别为40、262和3700 nM）。在体外抑制FGFR受体磷酸化（IC50 = 622 nM）和A121细胞的生长。

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：A selective FGFR inhibitorPD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.PD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.A selective FGFR inhibitor

IUPAC Name：1-tert-butyl-3-[6-(2,6-dichlorophenyl)-2-[4-(diethylamino)butylamino]pyrido[2,3-d]pyrimidin-7-yl]urea

INCHI：InChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36)

InChi Key：MKVMEJKNLUWFSQ-UHFFFAOYSA-N

Canonical SMILES：CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C

Isomeric SMILES：CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=C(C=CC=C3Cl)Cl)NC(=O)NC(C)(C)C

WGK Germany：3

PubChem CID：5328135

溶解性：溶于DMSO, 最高浓度 (mg/mL) 53.25, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 53.25, 最高浓度(mM) 100

敏感性：对空气敏感，对热敏感

熔点：157 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P316,P337+P317,P332+P317,P319

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