产品名称

英文名称：SMI-4a

同义词

SMI-4a、438190-29-5、SMI 4a、TCS PIM-1 4a、(Z)-SMI-4a、(5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione、(Z)-5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione、CHEMBL183906、(Z)-5-(3-(Trifluoromethyl)benzylidene)-thiazolidine-2,4-dione、(5

产品性质

CAS编号：438190-29-5

分子式：C11H6F3NO2S

分子量：273.23

MDL号：MFCD01152003

PubChem编号：1361334

英文别名：SMI-4a|438190-29-5|SMI 4a|TCS PIM-1 4a|(Z)-SMI-4a|(5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione|(Z)-5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione|CHEMBL183906|(Z)-5-(3-(Trifluoromethyl)benzylidene)-thiazolidine-2,4-dione|(5

规格或纯度：≥98%

英文名称：SMI-4a

生化机理：TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor (IC50 values = 24 and 100 nM for Pim-1 and Pim-2, respectively). TCS PIM-1 4a has been shown to display selectivity over a panel of approximately 50 other kinases tested. This compound also exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro. TCS PIM-1 4a is an inhibitor of Aldose Reductase and Cox-2.Potent, selective, cell-permeable, ATP-competitive Pim-1 kinase inhibitor (IC 50 =\xa017 nM). Moderately potent against Pim-2 kinase.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SMI-4a是一种有效的Pim1抑制剂，IC50为17 nM，作用于Pim-2适度有效，抑制其他丝/苏氨酸或酪氨酸激酶作用不显著。A selective and ATP-competitive Pim kinase inhibitorSMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.A selective and ATP-competitive Pim kinase inhibitor

IUPAC Name：(5Z)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione

INCHI：InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-

InChi Key：NGJLOFCOEOHFKQ-YVMONPNESA-N

Canonical SMILES：C1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2

Isomeric SMILES：C1=CC(=CC(=C1)C(F)(F)F)/C=C\2/C(=O)NC(=O)S2

WGK Germany：3

PubChem CID：1361334

溶解性：Soluble in DMSO (55 mg/ml at 25 °C), ethanol (32 mg/ml at 25 °C), and water (slightly at 25 °C).

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH317 May cause an allergic skin reaction

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P501,P272,P333+P313,P362+P364,P264+P265,P337+P317

产品包装