产品名称

英文名称：MLN2238

同义词

Ixazomib、1072833-77-2、MLN2238、MLN-2238、MLN 2238、(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid、Ixazomib [INN]、(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid、MLN-9708 FREE BASE、Ixazomib(MLN2238)、Ixazomib (MLN22

产品性质

CAS编号：1072833-77-2

分子式：C14H19BCl2N2O4

分子量：361.03

PubChem编号：25183872

英文别名：Ixazomib|1072833-77-2|MLN2238|MLN-2238|MLN 2238|(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid|Ixazomib [INN]|(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid|MLN-9708 FREE BASE|Ixazomib(MLN2238)|Ixazomib (MLN22

规格或纯度：≥98%

英文名称：MLN2238

生化机理：MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. MLN2238 is a selective, potent, and reversible inhibitor of the proteasome in tumor cells. MLN2238 shows time-dependent reversible proteasome inhibition.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、25mg、100mg卖完停产，不再备货

产品介绍：MLN2238(Ixazomib)能抑制20S蛋白酶体的糜蛋白酶样蛋白水解位点(β5)，IC50和Ki分别为3.4 nM和0.93 nM。MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM.

IUPAC Name：[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]boronic acid

INCHI：InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1

InChi Key：MXAYKZJJDUDWDS-LBPRGKRZSA-N

Canonical SMILES：B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O

Isomeric SMILES：B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O

PubChem CID：25183872

ChEMBL Ligand：CHEMBL2141296

CAS Registry No.：1072833-77-2

RCSB PDB Ligand：6V8

DrugCentral Ligand：5067

溶解性：DMSO 72 mg/mL Water <1 mg/mL Ethanol 9 mg/mL

象形图：

信号词：Danger

危险声明：H360 May damage fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P280,P405,P501,P264,P260,P270,P263,P203,P318

产品包装