产品名称

英文名称：Mefloquine Hydrochloride

同义词

Mefloquine hydrochloride、Mefloquine HCL、51773-92-3、Mephaquin、Loriam、WR 142490 hydrochloride、Ro 21-5998/001、NSC 157387、Mefloquine (hydrochloride)、EINECS 257-412-0、Mefloquine hydrochloride, (+)、DTXSID1047819、UNII-5Y9L3636O3、51742-86-0、5Y9L3636O3、NSC-157387、甲氟喹盐酸盐、(AS)-rel-a-(2R)-2-哌啶基-2,8-双(三氟甲基)-4-喹啉甲醇单盐酸盐

产品性质

CAS编号：51773-92-3

分子式：C17H16F6N2O·HCl

分子量：414.78

MDL号：MFCD00797519

PubChem编号：65329

别名：甲氟喹盐酸盐|(AS)-rel-a-(2R)-2-哌啶基-2,8-双(三氟甲基)-4-喹啉甲醇单盐酸盐

英文别名：Mefloquine hydrochloride|Mefloquine HCL|51773-92-3|Mephaquin|Loriam|WR 142490 hydrochloride|Ro 21-5998/001|NSC 157387|Mefloquine (hydrochloride)|EINECS 257-412-0|Mefloquine hydrochloride, (+)|DTXSID1047819|UNII-5Y9L3636O3|51742-86-0|5Y9L3636O3|NSC-157387|

规格或纯度：>98.0%(HPLC)

英文名称：Mefloquine Hydrochloride

生化机理：Cx36和Cx50间隙通道阻滞剂（IC50值分别为0.3和1.1μM）。阻止新皮层切片中神经元之间的间隙连接偶联。也抗疟疾。结合恶性疟原虫的80S核糖体抑制蛋白质合成。提高感染伯氏疟原虫的小鼠的存活率。另外在体外和体内均表现出抗血吸虫活性。表现出抗SARS-CoV-2（IC50 <10μM）的抗病毒活性。

应用：Mefloquine hydrochloride is a quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine.

运输条件：常规运输

产品介绍：Mefloquine hydrochloride is a quinoline antimalarial drμg that is structurally related to the antiarrhythmic agent quinidine.Mefloquine hydrochloride is a quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine.

PubChem SID：488183677

IUPAC Name：(S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2R)-piperidin-2-yl]methanol;hydrochloride

INCHI：InChI=1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1

InChi Key：WESWYMRNZNDGBX-YLCXCWDSSA-N

Canonical SMILES：C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl

Isomeric SMILES：C1CCN[C@H](C1)[C@H](C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl

WGK Germany：3

RTECS：VC0308000

PubChem CID：65329

溶解性：溶于ethanol, 最高浓度 (mg/mL) 41.48, 最高浓度(mM) 100；溶于DMSO, 最高浓度 (mg/mL) 20.74, 最高浓度(mM) 50

熔点：253 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Merck Index：5801

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装