产品名称

英文名称：CH5424802

同义词

AF 802、SR-01000389722-2、9-ETHYL-6,6-DIMETHYL-8-[4-(MORPHOLIN-4-YL)PIPERIDIN-1-YL]-11-OXO-5H,6H,11H-BENZO[B]CARBAZOLE-3-CARBONITRILE、9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile、Alectinib、艾乐替尼

产品性质

CAS编号：1256580-46-7

分子式：C30H34N4O2

分子量：482.62

PubChem编号：49806720

别名：艾乐替尼

英文别名：AF 802|SR-01000389722-2|9-ETHYL-6,6-DIMETHYL-8-[4-(MORPHOLIN-4-YL)PIPERIDIN-1-YL]-11-OXO-5H,6H,11H-BENZO[B]CARBAZOLE-3-CARBONITRILE|9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile|Alectinib

规格或纯度：≥98%

英文名称：CH5424802

生化机理：CH5424802 is an ATP-competitive inhibitor for ALK and L1196M with Ki values of 0.83 nM and 1.56 nM, respectively. CH5424802 prevents autophosphorylation of ALK, and also suppresses the phosphorylation of STAT3 and AKT, but not of ERK1/2. CH5424802 elicits an apoptotic marker—caspase-3/7-like activation—in NCI-H2228 spheroid cells. CH5424802 blocks the growth of two NPM-ALK expressing lymphoma lines, KARPAS-299 and SR with greater efficacy against KARPAS-299 at an IC50 of 3 nM.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Alectinib (CH5424802)是一种有效的ALK抑制剂，IC50为1.9 nM，对L1196M突变型敏感，作用于ALK比PF-02341066， NVP-TAE684和PHA-E429选择性高。An ATP-competitive inhibitor for ALK and L1196M.Alectinib (CH5424802) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429An ATP-competitive inhibitor for ALK and L1196M.

IUPAC Name：9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

INCHI：InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3

InChi Key：KDGFLJKFZUIJMX-UHFFFAOYSA-N

Canonical SMILES：CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C

Isomeric SMILES：CCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C

PubChem CID：49806720

ChEMBL Ligand：CHEMBL1738797

CAS Registry No.：1256580-46-7

RCSB PDB Ligand：EMH

PEP：alectinib

DrugCentral Ligand：4937

溶解性：DMSO ≥13mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

产品包装