产品名称

英文名称：MK-5108 (VX-689)

同义词

MK-5108、1010085-13-8、VX-689、MK 5108、MK5108、MK-5108 (VX-689)、VX689、VX 689、4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid、(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl

产品性质

CAS编号：1010085-13-8

分子式：C22H21ClFN3O3S

分子量：461.94

PubChem编号：24748204

英文别名：MK-5108|1010085-13-8|VX-689|MK 5108|MK5108|MK-5108 (VX-689)|VX689|VX 689|4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid|(1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl

规格或纯度：≥98%

英文名称：MK-5108 (VX-689)

生化机理：MK-5108 (VX-689) is a highly selective Aurora-A kinase inhibitor with an IC50 of 0.064 nM. MK-5108 is a novel small molecule with potent inhibitory activity against Aurora-A kinase. Althoμgh most of the Aurora-kinase inhibitors target both Aurora-A and Aurora-B, MK-5108 specifically inhibited Aurora-A kinase in a panel of protein kinase assays. Inhibition of Aurora-A by MK-5108 in cultured cells induced cell cycle arrest at the G2-M phase in flow cytometry analysis. The effect was confirmed by the accumulation of cells with expression of phosphorylated Histone H3 and inhibition of Aurora-A autophosphorylation by immunostaining assays. MK-5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. MK-5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. Furthermore, the combination of MK-5108 and docetaxel showed enhanced antitumor activities compared with control and docetaxel alone–treated animals without exacerbating the adverse effects of docetaxel. MK-5108 is currently tested in clinical trials and offers a new therapeutic approach to combat human cancers as a single agent or in combination with existing taxane therapies.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：MK-5108也叫VX-689，是一种新型有效选择性Aurora A激酶（AAK）抑制剂，通过竞争性结合AAK的ATP结合位点，有效抑制AAK活性，IC50值为0.064 nM。MK-5108对Aurora家族的其他激酶也有抑制作用，作用于Aurora B激酶的IC50值为14 nM，Aurora C激酶的IC50值为12 nM。MK-5108已被广泛研究，发现其对各种癌症包括乳腺癌、宫颈癌、结直肠癌、卵巢癌和胰腺癌均具有抗肿瘤活性。

ALogP：5.4

PubChem SID：488200675

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488200675

IUPAC Name：4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid

INCHI：InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)

InChi Key：LCVIRAZGMYMNNT-UHFFFAOYSA-N

Canonical SMILES：C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O

Isomeric SMILES：C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O

PubChem CID：24748204

CAS Registry No.：1010085-13-8

ChEMBL Ligand：CHEMBL3182444

溶解性：DMSO 92 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装