产品名称

英文名称：GSK2334470

同义词

GSK2334470、1227911-45-6、GSK 2334470、GSK-2334470、(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide、QB5BF4GJ87、CHEMBL1765740、PDK1 inhibitor GS2334470、(3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-

产品性质

CAS编号：1227911-45-6

分子式：C25H34N8O

分子量：462.59

MDL号：MFCD21608525

PubChem编号：46215815

英文别名：GSK2334470|1227911-45-6|GSK 2334470|GSK-2334470|(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide|QB5BF4GJ87|CHEMBL1765740|PDK1 inhibitor GS2334470|(3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-

规格或纯度：95%

英文名称：GSK2334470

生化机理：GSK2334470 is a highly specific and potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). GSK2334470 can be used in cells to ablate T-loop phosphorylation and activate SGK, S6K1 and RSK as well as suppress the activation of Akt.Novel, potent PDK1 (3-phosphoinositide-dependent protein kinase 1)\xa0inhibitor (IC 50 = ~10 nM) with no activity at other close related AGC-kinases.\xa0Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：GSK2334470是PDK1抑制剂，IC50为10 nM，对别的相关AGC激酶无活性。A potent and selective PDK1 inhibitor that subsequently induces apoptotic cell deathGSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases.A potent and selective PDK1 inhibitor that subsequently induces apoptotic cell death

PubChem SID：488201269

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488201269

IUPAC Name：(3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl]-N-cyclohexyl-6-methylpiperidine-3-carboxamide

INCHI：InChI=1S/C25H34N8O/c1-15-8-9-17(24(34)28-18-6-4-3-5-7-18)14-33(15)22-13-20(29-25(27-2)30-22)16-10-11-19-21(12-16)31-32-23(19)26/h10-13,15,17-18H,3-9,14H2,1-2H3,(H,28,34)(H3,26,31,32)(H,27,29,30)/t15-,17+/m1/s1

InChi Key：QLPHOXTXAKOFMU-WBVHZDCISA-N

Canonical SMILES：CC1CCC(CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5

Isomeric SMILES：C[C@@H]1CC[C@@H](CN1C2=NC(=NC(=C2)C3=CC4=C(C=C3)C(=NN4)N)NC)C(=O)NC5CCCCC5

WGK Germany：3

PubChem CID：46215815

CAS Registry No.：1227911-45-6

ChEMBL Ligand：CHEMBL1765740

溶解性：DMSO 90 mg/mL Water <1 mg/mL Ethanol 90 mg/mL

产品包装