产品名称

英文名称：Cobicistat (GS-9350)

同义词

1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate、COBICISTAT [WHO-DD]、Thiazol-5-ylmethyl ((1R,4R)-1-benzyl-4-(((2S)-2-((methyl((2、可比司他

产品性质

CAS编号：1004316-88-4

分子式：C40H53N7O5S2

分子量：776.02

PubChem编号：25151504

别名：可比司他

英文别名：1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate|COBICISTAT [WHO-DD]|Thiazol-5-ylmethyl ((1R,4R)-1-benzyl-4-(((2S)-2-((methyl((2

规格或纯度：≥98%

英文名称：Cobicistat (GS-9350)

生化机理：Cobicistat is a drμg under experimental investigation for use in the treatment of infection with the human immunodeficiency virus (HIV). Like ritonovir (Norvir), cobicistat is of interest not for its anti-HIV properties, but rather its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor currently under investigation itself. By combining cobicistat with elvitegravir, higher concentrations of elvitgravir are achieved in the body with lower dosing, theoretically enhancing elvitgravir's viral suppression while diminishing its adverse side-effects. In contrast with ritonavir, the only currently approved booster, cobicistat has no anti-HIV activity of its own…From Wikipedia.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Cobicistat (GS-9350)是一种有效的CYP3A选择性抑制剂，IC50为30 - 285 nM。Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.

ALogP：5.7

IUPAC Name：1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

INCHI：InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1

InChi Key：ZCIGNRJZKPOIKD-CQXVEOKZSA-N

Canonical SMILES：CC(C)C1=NC(=CS1)CN(C)C(=O)NC(CCN2CCOCC2)C(=O)NC(CCC(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5

Isomeric SMILES：CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5

PubChem CID：25151504

CAS Registry No.：1004316-88-4

ChEBI：CHEBI72291

ChEMBL Ligand：CHEMBL2095208

Wikipedia：Cobicistat

DrugCentral Ligand：4299

溶解性：DMSO mg/mL Water mg/mL Ethanol mg/mL

产品包装