产品名称

英文名称：Wnt-C59 (C59)

同义词

Wnt-C59、1243243-89-1、2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide、C25H21N3O、2-[4-(2-Methyl-pyridin-4-yl)-phenyl]-N-(4-pyridin-3-yl-phenyl)-acetamide、Wnt-C59 (C59)、CHEMBL2139947、2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-yl

产品性质

CAS编号：1243243-89-1

分子式：C25H21N3O

分子量：379.45

PubChem编号：57519544

英文别名：Wnt-C59|1243243-89-1|2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide|C25H21N3O|2-[4-(2-Methyl-pyridin-4-yl)-phenyl]-N-(4-pyridin-3-yl-phenyl)-acetamide|Wnt-C59 (C59)|CHEMBL2139947|2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-yl

规格或纯度：≥98%

英文名称：Wnt-C59 (C59)

生化机理：C59 inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by inhibition of Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity . Wnt-C59 was used at 0.1-0.2 μM to completely block Wnt protein secretion. When used at 0.5 μM, it can be used functionally replace the Dkk protein in many assay conditions.Potent Wnt signaling pathway inhibitor. Inhibits porcupine (PORCN) required for Wnt palmitoylation, secretion, and biological activity. Inhibits Wnt-mediated transcription (IC 50 = 74 pM) and cell proliferation. Active in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Wnt-C59(C59)是高活性Wnt信号转导拮抗剂，IC50为74 pM。A porcupine homolog - Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferaseWnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.A porcupine homolog - Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase

IUPAC Name：2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide

INCHI：InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)

InChi Key：KHZOJCQBHJUJFY-UHFFFAOYSA-N

Canonical SMILES：CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4

Isomeric SMILES：CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4

PubChem CID：57519544

ChEMBL Ligand：CHEMBL2139947

BindingDB Ligand：50133864

CAS Registry No.：1243243-89-1

溶解性：DMSO 76 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装