产品名称

英文名称：LCL161

同义词

LCL161、1005342-46-0、LCL-161、(s)-n-((s)-1-cyclohexyl-2-((s)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide、LCL 161、Nvp-lcl 161、NVP-LCL161、6TNS415Y3P、CHEMBL2431768、(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorob

产品性质

CAS编号：1005342-46-0

分子式：C26H33FN4O3S

分子量：500.63

PubChem编号：24737642

英文别名：LCL161|1005342-46-0|LCL-161|(s)-n-((s)-1-cyclohexyl-2-((s)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide|LCL 161|Nvp-lcl 161|NVP-LCL161|6TNS415Y3P|CHEMBL2431768|(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorob

规格或纯度：≥99%

英文名称：LCL161

生化机理：DescriptionIC50 Value N/ALCL161 is an oral small molecule antagonist of Inhibitor of Apoptosis Proteins (IAPs) that sensitizes a subset of tumors from diverse lineages to treatment with cytotoxic therapies.in vitro Huh-7 cells co-treated with LCL161 and SC-2001 showed a significant dose-dependent apoptotic effect demonstrated by sub-G1 assay and cleavage of PARP. Furthermore, the combination index (CI) ofLCL161 and SC-2001 showed a convincing synergism in resistant Huh-7 [1]. Results in human liver microsomes indicated LCL161 inhibited CYP3A in a concentration- and time-dependent manner (KI of 0.797??M and kinact of 0.0803?min(-1) ). LCL161 activated human PXR in a reporter gene assay and induced CYP3A4 mRNA up to ?5-fold in human hepatocytes [2]. LCL161 caused rapid degradation of cIAP1 leading to TNFα secretion, LCL161 did not promote apoptosis significantly. However, LCL161 induced expression of MICA and MICB, ligands for the activating im.Small molecule SMAC mimetic inhibitor of multiple IAP (Inhibitor of apoptosis) family proteins.\xa0 (IC 50 = 10.23 μM). Inhibits cell proliferation and viability in two human hepatocellular carcinoma cells (Hep3B, \xa0IC 50 =\xa010, and PLC5, IC 50 = 19).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：LCL161，一个SMAC模拟的，能有效地结合并抑制多元IAPs(i.e. XIAP, c-IAP)。Phase 2。LCL161, a SMAC mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). Phase 2.

IUPAC Name：(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide

INCHI：InChI=1S/C26H33FN4O3S/c1-16(28-2)24(33)30-22(17-7-4-3-5-8-17)26(34)31-14-6-9-21(31)25-29-20(15-35-25)23(32)18-10-12-19(27)13-11-18/h10-13,15-17,21-22,28H,3-9,14H2,1-2H3,(H,30,33)/t16-,21-,22-/m0/s1

InChi Key：UFPFGVNKHCLJJO-SSKFGXFMSA-N

Canonical SMILES：CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

Isomeric SMILES：C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

PubChem CID：24737642

ChEMBL Ligand：CHEMBL2431768

CAS Registry No.：1005342-46-0

溶解性：25°C DMSO

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装