产品名称

英文名称：ML133 HCl

同义词

1222781-70-5、ML133 HCL、(4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride、ML133 hydrochloride、ML 133 hydrochloride、N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride、ML133 (hydrochloride)、(4-Methoxybenzyl)(1-naphthylmethyl)amine HCl、(4-m、(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐

产品性质

CAS编号：1222781-70-5

分子式：C19H19NO.HCl

分子量：313.82

MDL号：MFCD20921521

PubChem编号：44247466

别名：(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐

英文别名：1222781-70-5|ML133 HCL|(4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride|ML133 hydrochloride|ML 133 hydrochloride|N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride|ML133 (hydrochloride)|(4-Methoxybenzyl)(1-naphthylmethyl)amine HCl|(4-m

规格或纯度：≥98%

英文名称：ML133 HCl

生化机理：内向整流Kir2钾离子通道的选择性阻滞剂（在pH 7.4时，mKir2.1，hKir2.6，hKir2.2和hKir2.3的IC50值为1.8、2.8、2.9和4.0μM）。对rKir1.1（IC50>300μM）无影响;在hKir7.1和rKir4.1处显示弱活性（IC50值为33和76μM）。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：5mg、50mg、10mg卖完停产，不再备货

产品介绍：ML133 HCl是一种选择性钾离子通道抑制剂，作用于Kir2.1， IC50为1.8 μM (pH 7.4)和290 nM (pH 8.5)，对Kir1.1没有作用效果，对Kir4.1和Kir7.1具有微弱的作用活性。ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.

IUPAC Name：1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride

INCHI：InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H

InChi Key：NGQIBUUFXDPHKT-UHFFFAOYSA-N

Canonical SMILES：COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl

Isomeric SMILES：COC1=CC=C(C=C1)CNCC2=CC=CC3=CC=CC=C32.Cl

WGK Germany：3

PubChem CID：44247466

溶解性：溶于DMSO, 最高浓度 (mg/mL) 31.38, 最高浓度(mM) 100

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH335 May cause respiratory irritationH302 Harmful if swallowedH318 Causes serious eye damageH400 Very toxic to aquatic life

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P264+P265,P301+P317,P305+P354+P338,P317,P332+P317,P319

产品包装