产品名称

英文名称：360A

同义词

360 A；3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium]、360 A

产品性质

CAS编号：794458-56-3

分子式：C27H23N5O2

分子量：449.5

PubChem编号：11430774

别名：360 A

英文别名：360 A；3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium]

规格或纯度：98%

英文名称：360A

生化机理：DescriptionIC50 Value N/A360A is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for G-quadruplex structures and selective telomerase inhibition in vitro assays. 360A is a G-quadruplex ligand, which can influence the consequence of G-quadruplex formation and/or stabilization.in vitro We found a S-phase accumulation in ATM-proficient, but not in ATM-deficient EBV-lymphocytes treated with 360A before induction of cell death. However, ATM status did not modify cell cycle distribution in 360A-treated SV40-fibroblasts and HeLa cells compared to DMSO treated controls [1]. DNA-PKcs-dependent NHEJ was responsible for sister telomere fusions as a direct consequence of G-quadruplex formation and/or stabilization induced by 360A on parental telomere G strands. NHEJ and HR activation at telomeres altered mitotic progression in treated cells [2]. This compound was shown to display a potent affinity and selectivity for telomeri

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25mg、100mg卖完停产，不再备货

产品介绍：360A是G-四联体结构高亲和性抑制剂。360A is a strong affinity and selectivity inhibitor of G-quadruplex structures.

IUPAC Name：2-N,6-N-bis(1-methylquinolin-1-ium-3-yl)pyridine-2,6-dicarboxamide

INCHI：InChI=1S/C27H21N5O2/c1-31-16-20(14-18-8-3-5-12-24(18)31)28-26(33)22-10-7-11-23(30-22)27(34)29-21-15-19-9-4-6-13-25(19)32(2)17-21/h3-17H,1-2H3/p+2

InChi Key：KPOOEJJPTYXNTN-UHFFFAOYSA-P

Canonical SMILES：C[N+]1=CC(=CC2=CC=CC=C21)NC(=O)C3=NC(=CC=C3)C(=O)NC4=CC5=CC=CC=C5[N+](=C4)C

Isomeric SMILES：C[N+]1=CC(=CC2=CC=CC=C21)NC(=O)C3=NC(=CC=C3)C(=O)NC4=CC5=CC=CC=C5[N+](=C4)C

PubChem CID：11430774

溶解性：25°C DMSO

产品包装