产品名称

英文名称：5-Aza-2′-deoxycytidine

同义词

Decitabine、5-Aza-2'-deoxycytidine、2353-33-5、Dacogen、2'-Deoxy-5-azacytidine、5-Azadeoxycytidine、AzadC、5-aza-CdR、5-aza-dC、Dezocitidine、5-Aza-deoxycytidine、5-AZAdC、2-deoxyazacytidine、Dac、NSC 127716、4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofu、5-氮杂-2'-脱氧胞苷、5-氮杂-1-(2-脱氧-β-D-呋喃核糖基)胞嘧啶、地西他滨 2'-脱氧-5-氮杂胞苷、4-氨基-1-(2-脱氧-β-D-呋喃核糖基)-1,3,5-三嗪-2(1H)- 酮

产品性质

CAS编号：2353-33-5

分子式：C8H12N4O4

分子量：228.21

Beilstein号：617982

EC号：219-089-4

MDL号：MFCD00043011

PubChem编号：451668

别名：5-氮杂-2'-脱氧胞苷|5-氮杂-1-(2-脱氧-β-D-呋喃核糖基)胞嘧啶|地西他滨 2'-脱氧-5-氮杂胞苷|4-氨基-1-(2-脱氧-β-D-呋喃核糖基)-1,3,5-三嗪-2(1H)- 酮|

英文别名：Decitabine|5-Aza-2'-deoxycytidine|2353-33-5|Dacogen|2'-Deoxy-5-azacytidine|5-Azadeoxycytidine|AzadC|5-aza-CdR|5-aza-dC|Dezocitidine|5-Aza-deoxycytidine|5-AZAdC|2-deoxyazacytidine|Dac|NSC 127716|4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofu

规格或纯度：98%

英文名称：5-Aza-2′-deoxycytidine

生化机理：5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.Potent DNA methyltransferase 1 (DNMT1) inhibitor (IC 50 = 0.2 μM). Incorporated into DNA, inhibits DNMT1 activity to induce DNA hypomethylation. Interferes with protein synthesis. Shows antimetabolic and anticancer activities in vitro . Active in vivo .

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.

PubChem SID：488189867

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488189867

IUPAC Name：4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

INCHI：InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1

InChi Key：XAUDJQYHKZQPEU-KVQBGUIXSA-N

Canonical SMILES：C1C(C(OC1N2C=NC(=NC2=O)N)CO)O

Isomeric SMILES：C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O

WGK Germany：3

RTECS：XZ3012000

PubChem CID：451668

DrugBank Ligand：DB01262

CAS Registry No.：2353-33-5

ChEMBL Ligand：CHEMBL1201129

Wikipedia：Decitabine

ChEBI：CHEBI50131

DrugCentral Ligand：790

敏感性：对光线敏感;对热敏感

熔点：191 °C(dec.)

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH341 Suspected of causing genetic defectsH302 Harmful if swallowedH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P281,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

Merck Index：2853

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装