产品名称

英文名称：Raloxifene HCl

同义词

RALOXIFENE HYDROCHLORIDE、82640-04-8、Raloxifene Hcl、Evista、Keoxifene hydrochloride、Keoxifene、Optruma、Raloxifene Teva、(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone hydrochloride、Raloxifene (hydrochloride)、盐酸雷洛昔芬

产品性质

CAS编号：82640-04-8

分子式：C28H27NO4S·HCl

分子量：510.04

PubChem编号：54900

别名：盐酸雷洛昔芬

英文别名：RALOXIFENE HYDROCHLORIDE|82640-04-8|Raloxifene Hcl|Evista|Keoxifene hydrochloride|Keoxifene|Optruma|Raloxifene Teva|(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone hydrochloride|Raloxifene (hydrochloride)|

规格或纯度：≥98%

英文名称：Raloxifene HCl

生化机理：Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM), binding to ERα and ERβ. Tissue-dependently blocks or activates estrogen-induced transcription. Exhibits estrogen agonist behavior in bone but acts as an anti-estrogen in breast and uterine tissue. Raloxifene hydrochloride exhibits inhibitory effects of progesterone receptor induction by estrogen in D12 rat hypothalamic cells. Raloxifene hydrochloride is a substrate of Estrogen Receptor.Selective estrogen receptor modulator (SERM). Binds to both ER α (K d = 90pM) and ER β . Tissue-dependently inhibits or activates ER-induced transcription. Inhibits estradiol-induced progesterone receptor activity in hypothalamic cells (IC 50 = 1nM).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Raloxifene HCl是estrogen（雌性激素）拮抗剂，抑制人体胞浆醛氧化酶催化的酞嗪氧化活性，IC50为5.7 nM。A SERM of ERα and ERβ.Raloxifene is an estrogen antagonist, which inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM.A SERM of ERα and ERβ.

IUPAC Name：[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone;hydrochloride

INCHI：InChI=1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H

InChi Key：BKXVVCILCIUCLG-UHFFFAOYSA-N

Canonical SMILES：C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl

Isomeric SMILES：C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl

WGK Germany：3

PubChem CID：54900

溶解性：Soluble in DMSO (50 mM), methanol, and ethanol (<1 mg/ml at 25 °C). Insoluble in water.

象形图：

信号词：Danger

危险声明：H351 Suspected of causing cancerH411 Toxic to aquatic life with long lasting effectsH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH360 May damage fertility or the unborn child

预防措施声明：P273,P280,P405,P501,P391,P203,P318

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装