产品名称

英文名称：Cytochalasin B

同义词

C19954、IDI1_034070、MLS002703001、SCHEMBL9046718、2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-、BDBM50478403、B、松胞菌素B

产品性质

CAS编号：14930-96-2

分子式：C29H37NO5

分子量：479.61

Beilstein号：1096207

EC号：239-000-2

MDL号：MFCD00077704

PubChem编号：5311281

别名：松胞菌素B

英文别名：C19954|IDI1_034070|MLS002703001|SCHEMBL9046718|2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-|BDBM50478403|B

规格或纯度：98%

英文名称：Cytochalasin B

生化机理：One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts. .Cell permeable actin polymerization inhibitor. Reversible K V 1.5 blocker (IC 50 = 4 μM). Inhibits I(Kur). Cytochalasin A analog. Inhibits transport of monosaccharides across the cell membrane. Shows antitumor effects in vivo.

储存温度：避光,-20°C储存,干燥

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Cytochalasin B is used in actin polymerization studies and cytological research. Cytochalasin B is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. As opposed to other Cytochalasins, cytochalasin A and Cytochalasin B bind to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Cytochalasin B inhibits phagocytosis by both mononuclear phagocytes and polymorphonuclear leukocytes.A cell-permeable fungal toxin used in actin polymerization studies and cytologicalCytochalasin B is used in actin polymerization studies and cytological research. Cytochalasin B is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. As opposed to other Cytochalasins, cytochalasin A and Cytochalasin B bind to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Cytochalasin B inhibits phagocytosis by both mononuclear phagocytes and polymorphonuclear leukocytesA cell-permeable fungal toxin used in actin polymerization studies and cytological

IUPAC Name：(1S,4E,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicosa-4,12-diene-3,21-dione

INCHI：InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1

InChi Key：GBOGMAARMMDZGR-TYHYBEHESA-N

Canonical SMILES：CC1CCCC(C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O

Isomeric SMILES：C[C@@H]1CCC[C@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)CC4=CC=CC=C4)C)O)O

WGK Germany：3

RTECS：RO0205000

PubChem CID：5311281

UN Number：1544

Wikipedia：Cytochalasin_B

CAS Registry No.：14930-96-2

ChEBI：CHEBI23527

ChEMBL Ligand：CHEMBL411729

RCSB PDB Ligand：5RH

溶解性：Soluble in methanol (20 mg/ml), and 120 DMFPBS(7.2) (~0.05 mg/ml).

密度：1.2

敏感性：对热敏感；对光敏感；对湿度敏感

熔点：218-223°C

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowedH310 Fatal in contact with skinH330 Fatal if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P301+P310,P264,P260,P284,P302+P350

个人防护装备：Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装