产品名称

英文名称：SP600125

同义词

HMS1362F07、KBioGR_000406、Anthra[1-9-cd]pyrazol-6(2H)-one、SDCCGSBI-0050458.P003、WLN T C66651A P IV OMNJ、Pyrazolanthrone、Pyrazoleanthrone、HMS3295M01、2,6-dihydrodibenzo[cd,g]indazol-6-one、JMC517015 Compound 2、Bio1_001313、NCGC00015958-02、SP600125、SP-600125、s、吡唑蒽酮

产品性质

CAS编号：129-56-6

分子式：C14H8N2O

分子量：220.233

MDL号：MFCD00022289

PubChem编号：8515

别名：吡唑蒽酮

英文别名：HMS1362F07|KBioGR_000406|Anthra[1-9-cd]pyrazol-6(2H)-one|SDCCGSBI-0050458.P003|WLN T C66651A P IV OMNJ|Pyrazolanthrone|Pyrazoleanthrone|HMS3295M01|2,6-dihydrodibenzo[cd,g]indazol-6-one|JMC517015 Compound 2|Bio1_001313|NCGC00015958-02|SP600125|SP-600125|s

规格或纯度：≥98%

英文名称：SP600125

生化机理：SP600125 is selective inhibitor of c-Jun N-terminal kinase (JNK). SP600125 competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 μM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.Potent and selective JNK1, -2, and -3 inhibitor (IC 50 = 0.11 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity over a range of kinases. It dose-dependently inhibits the phosphorylation of c-Jun and the expression of inflam

应用：A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SP600125是泛JNK抑制剂，对JNK1，JNK2和JNK3的IC50分别为40 nM，40 nM和90 nM，比对MKK4和MKK3，MKK6，PKB，PKCα的抑制性高10倍和超过25倍。A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM in cell-free assays, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3

IUPAC Name：14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-8-one

INCHI：InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)

InChi Key：ACPOUJIDANTYHO-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O

Isomeric SMILES：C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O

PubChem CID：8515

CAS Registry No.：129-56-6

Wikipedia：1,9-Pyrazoloanthrone

RCSB PDB Ligand：537

溶解性：DMSO ≥42mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

敏感性：对热敏感

熔点：283°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装