产品名称

英文名称：Pitavastatin Calcium

同义词

Pitavastatin calcium、147526-32-7、Pitavastatin hemicalcium、Livalo、Itavastatin calcium、NK-104、Flovas、Pitavastatin calcium salt、UNII-IYD54XEG3W、IYD54XEG3W、NK 104 (acid)、Nisvastatin、CCRIS 8652、Calcium (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl、匹伐他汀钙

产品性质

CAS编号：147526-32-7

分子式：C50H46CaF2N2O8

分子量：880.98

PubChem编号：5282451

别名：匹伐他汀钙

英文别名：Pitavastatin calcium|147526-32-7|Pitavastatin hemicalcium|Livalo|Itavastatin calcium|NK-104|Flovas|Pitavastatin calcium salt|UNII-IYD54XEG3W|IYD54XEG3W|NK 104 (acid)|Nisvastatin|CCRIS 8652|Calcium (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl

规格或纯度：≥99%

英文名称：Pitavastatin Calcium

生化机理：Pitavastatin Calcium 是一种新型的Statins类药物。Potent, competitive inhibitor of HMG-CoA reductase (K i = 1.7nM). Blocks cholesterol synthesis. Displays cardioprotective properties. Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.A competitive inhibitor of HMG-CoA reductasePitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.A competitive inhibitor of HMG-CoA reductase

PubChem SID：488195263

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195263

IUPAC Name：calcium;(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate

INCHI：InChI=1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1

InChi Key：RHGYHLPFVJEAOC-FFNUKLMVSA-L

Canonical SMILES：C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]

Isomeric SMILES：C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2]

关联CAS：147511-69-1

PubChem CID：5282451

溶解性：DMSO 51 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H361f Suspected of damaging fertility

预防措施声明：P280,P405,P501,P201,P308+P313,P202

产品包装