产品名称

英文名称：Colchicine

同义词

COLBENEMID COMPONENT COLCHICINE、Colchicin、COLCHICINE [MI]、EINECS 200-598-5、HSDB 3044、COLCHICINE [HSDB]、COLCIGEL、7JX9WZ3SJ5、COLCHICINE [EP IMPURITY]、Colchicine Tablets 0.5 mg、Condylon、Kolkicin、N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]h、秋水仙素

产品性质

CAS编号：64-86-8

分子式：C22H25NO6

分子量：399.44

Beilstein号：2228813

EC号：200-598-5

MDL号：MFCD00078484

PubChem编号：6167

别名：秋水仙素

英文别名：COLBENEMID COMPONENT COLCHICINE|Colchicin|COLCHICINE [MI]|EINECS 200-598-5|HSDB 3044|COLCHICINE [HSDB]|COLCIGEL|7JX9WZ3SJ5|COLCHICINE [EP IMPURITY]|Colchicine Tablets 0.5 mg|Condylon|Kolkicin|N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]h

规格或纯度：分析标准品,≥99%(HPLC)

英文名称：Colchicine

生化机理：Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM). Studies indicate that Colchicine also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis. Since increased rate of mitosis is associated with cancer cell proliferation, blocking microtubule function with Colchicine has been used as an approach to anti-cancer therapy. For instance, Colchicine blocks the growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine produces anti-inflammatory effects by inhibiting neutrophil motility and activity (5 μmol/kg in a mouse model of gouty arthritis) and inhibits the deposition of uric acid, a key aspect in the treatment of gout.

储存温度：避光,干燥

运输条件：常规运输

产品介绍：遇光变暗。易溶于乙醇、氯仿，溶于水、乙醚、苯，不溶于石油醚；溶解度45g/L (20°C)、1g/220ml 乙醚、1g/100ml 苯。pK（20℃）=12.35，pH值5.9。因其氮原子在侧链上是酰胺结构，故不呈碱性。 秋水仙碱是染色体研究中不可缺少的试剂。抗有丝分裂试剂，靠结合微管蛋白（tubulin）阻断微管聚合。 激活微管蛋白内在的GTPase活性。 在几种正常和肿瘤细胞株上诱导细胞凋亡，激活 JNK/SAPK 信号传导途径。Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis.

IUPAC Name：N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

INCHI：InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChi Key：IAKHMKGGTNLKSZ-INIZCTEOSA-N

Canonical SMILES：CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Isomeric SMILES：CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

WGK Germany：3

RTECS：GH0700000

PubChem CID：6167

UN Number：1544

Packing Group：I

溶解性：Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol., Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol.

密度：1.32

敏感性：对光敏感

比旋光度：-238° (C=1,EtOH)

熔点：150-160°C

象形图：

信号词：Danger

危险声明：H300 Fatal if swallowedH340 May cause genetic defects

预防措施声明：P321,P405,P501,P264,P281,P270,P330,P203,P301+P316,P318

Class：6.1

Merck Index：2471

个人防护装备：Eyeshields,Faceshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

产品包装