产品名称

英文名称：Fluocinolone Acetonide

同义词

FLUOCINOLONE ACETONIDE、67-73-2、Synalar、Fluonid、Synamol、Synandone、Coriphate、Dermalar、Flucinar、Fluovitif、Flupollon、Percutina、Radiocin、Retisert、Synandrone、Tefunote、Jellin、Localyn、Sinalar、Synemol、Synotic、Synsac、Fluocet、Omniderm、Derma-smoothe/fs、Synalar-HP、Flu、醋酸肤轻松、仙乃乐、乙酸肤轻松、6α,9α-二氟-11β,16α,17α,21-四羟基-1,4-孕甾二烯-3,20-二酮16,17-缩丙酮

产品性质

CAS编号：67-73-2

分子式：C24H30F2O6

分子量：452.49

EC号：200-668-5

MDL号：MFCD00010525

PubChem编号：6215

别名：醋酸肤轻松|仙乃乐|乙酸肤轻松|6α,9α-二氟-11β,16α,17α,21-四羟基-1,4-孕甾二烯-3,20-二酮16,17-缩丙酮

英文别名：FLUOCINOLONE ACETONIDE|67-73-2|Synalar|Fluonid|Synamol|Synandone|Coriphate|Dermalar|Flucinar|Fluovitif|Flupollon|Percutina|Radiocin|Retisert|Synandrone|Tefunote|Jellin|Localyn|Sinalar|Synemol|Synotic|Synsac|Fluocet|Omniderm|Derma-smoothe/fs|Synalar-HP|Flu

规格或纯度：≥98%

英文名称：Fluocinolone Acetonide

生化机理：Fluocinolone Acetonide is a synthetic glucocorticoid which acts as an inhibitor of tumor cells. Studies indicate that Fluocinolone Acetonide can inhibit promotion of tumor cells at an early stage of promotion if combined with a promoting agent. In addition, studies sμggest that Fluocinolone Acetonide can regulate lipid metabolism by modulating gene expression. Alternate studies show that Fluocinolone Acetonide can inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, Fluocinolone Acetonide can inhibit TNF-α angiogenesis.Potent synthetic corticosteroid (EC 50 = 2 nM at glucocorticoid receptor). Inhibits VEGF secretion and expression. Inhibits proliferation and TNF-α-induced angiogenesis. Shows anti-inflammatory and neuroprotective effects in vivo.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Fluocinolone Acetonide是一种皮质类固醇，与胞浆中糖皮质激素受体结合。A synthetic glucocorticoid VEGF inhibitor.Fluocinolone Acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor.A synthetic glucocorticoid VEGF inhibitor.

ALogP：2.5

IUPAC Name：(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

INCHI：InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChi Key：FEBLZLNTKCEFIT-VSXGLTOVSA-N

Canonical SMILES：CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)F)C

Isomeric SMILES：C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@@]53C)F)F)O

WGK Germany：3

RTECS：TU3830000

PubChem CID：6215

DrugBank Ligand：DB00591

CAS Registry No.：67-73-2

ChEMBL Ligand：CHEMBL989

Wikipedia：Fluocinolone acetonide

DrugCentral Ligand：1204

溶解性：DMSO 90 mg/mL Water Ethanol 12 mg/mL

熔点：267-269°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装