产品名称

英文名称：Lansoprazole

同义词

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole、Compraz、Lansoprazole-13C6、Lansoprazole [USANUSPINNBAN]、Prevacid SoluTab、2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole、LANSOPRAZOLE (、兰索拉唑

产品性质

CAS编号：103577-45-3

分子式：C16H14F3N3O2S

分子量：369.36

MDL号：MFCD00866873

PubChem编号：3883

别名：兰索拉唑

英文别名：2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole|Compraz|Lansoprazole-13C6|Lansoprazole [USANUSPINNBAN]|Prevacid SoluTab|2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole|LANSOPRAZOLE (

规格或纯度：≥98%

英文名称：Lansoprazole

生化机理：具有抗分泌和抗溃疡活性的H +，K + -ATPase抑制剂（IC50 =6.3μM）。抑制胃酸分泌（组胺诱导的酸形成的IC50 =0.09μM）并减少各种溃疡性刺激引起的胃部病变的形成。体外抗幽门螺杆菌。还可以阻断NIH3T3成纤维细胞中的溶胀依赖性氯离子通道（ICIswell）。比奥美拉唑更有效。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：250mg卖完停产，不再备货

产品介绍：Lansoprazole is a ATP4A (H+,K+-ATPase) inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICI swell) in NIH3T3 fibroblasts. Lansoprazole is more potent than omeprazoleA H+,K+-ATPase inhibitor that displays antisecretory activityLansoprazole is a ATP4A (H+,K+-ATPase) inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICI swell) in NIH3T3 fibroblasts. Lansoprazole is more potent than omeprazoleA H+,K+-ATPase inhibitor that displays antisecretory activity

ALogP：2.8

IUPAC Name：2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole

INCHI：InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)

InChi Key：MJIHNNLFOKEZEW-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F

Isomeric SMILES：CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F

WGK Germany：2

RTECS：DD9487500

PubChem CID：3883

Reaxy-Rn：4333393

DrugBank Ligand：DB00448

CAS Registry No.：103577-45-3

ChEMBL Ligand：CHEMBL480

Wikipedia：lansoprazole

PEP：lansoprazole

DrugCentral Ligand：1547

溶解性：溶于1eq. HCl, 最高浓度 (mg/mL) 18.47, 最高浓度(mM) 50；溶于DMSO, 最高浓度 (mg/mL) 36.94, 最高浓度(mM) 100

敏感性：对热敏感

熔点：173-175°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：5362

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装