产品名称

英文名称：SC-560

同义词

SC-560、188817-13-2、5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole、SC 560、SC560、5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)pyrazole、5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole、CHEMBL26915、CHEBI76、5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑

产品性质

CAS编号：188817-13-2

分子式：C17H12ON2ClF3

分子量：352.74

MDL号：MFCD02179214

PubChem编号：4306515

别名：5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑

英文别名：SC-560|188817-13-2|5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole|SC 560|SC560|5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)pyrazole|5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole|CHEMBL26915|CHEBI76

规格或纯度：≥98%(HPLC)

英文名称：SC-560

生化机理：SC 560 is reported to be a Cox-1 and Cox-2 inhibitor, and is highly selective for Cox-1 (IC50 of 0.009 μM) over Cox-2 (IC50 of 6.3 μM). SC 560 also inhibits UTP-stimulated and basal cAMP levels. Cox-1 is shown to catalyze the conversion of Arachidonic Acid (204, n-6) (sc-200770) into PGH2 (Prostaglandin H2, sc-201266), which is the precursor of thromboxanes and other prostaglandins, therefore SC 560 also suppresses TXB2 (Thromboxane B2, sc-201452) and PGE2 (Prostaglandin E2, sc-201225) production. SC 560 also displays the ability to induce cell growth inhibition by causing cell cycle arrest at the G1 phase. Mechanistic studies show that SC 560 causes apoptosis of cells by eliciting reactive oxygen species and simultaneously decreasing the levels of anti-apoptotic proteins XIAP and survivin. Additional experiments sμggest that SC 560 also activates caspase-3 and caspase-7 which results in apoptosis of cells.Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC 50 values are 9 nM and 6.3 μM for COX-1 and COX-2, respectively). Displays anti-inflammatory, antitumor and antiviral activity. Orally active.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Selective cyclooxygenase-1 (COX-1) inhibitor, exhibiting 700-fold selectivity for COX-1 over COX-2.A highly potent and selective inhibitor of Cox-1Selective cyclooxygenase-1 (COX-1) inhibitor, exhibiting 700-fold selectivity for COX-1 over COX-2.A highly potent and selective inhibitor of Cox-1

IUPAC Name：5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)pyrazole

INCHI：InChI=1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3

InChi Key：PQUGCKBLVKJMNT-UHFFFAOYSA-N

Canonical SMILES：COC1=CC=C(C=C1)N2C(=CC(=N2)C(F)(F)F)C3=CC=C(C=C3)Cl

Isomeric SMILES：COC1=CC=C(C=C1)N2C(=CC(=N2)C(F)(F)F)C3=CC=C(C=C3)Cl

WGK Germany：3

PubChem CID：4306515

ChEMBL Ligand：CHEMBL26915

BindingDB Ligand：13065

CAS Registry No.：188817-13-2

密度：1.33

敏感性：对热敏感

沸点：440.58° C at 760 mmHg

熔点：1.56

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装