N-对甲苯磺酰基-L-苯丙氨酸氯甲基酮

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产品名称

中文名称：N-对甲苯磺酰基-L-苯丙氨酸氯甲基酮

英文名称：N-alpha-Tosyl-L-phenylalanylchloromethane

产品性质

产品编号：LY-TRCT686000

CAS 号：402-71-1

英文名称：N-alpha-Tosyl-L-phenylalanylchloromethane

中文名称：N-对甲苯磺酰基-L-苯丙氨酸氯甲基酮

分子式：C17 H18 Cl N O3 S

分子量：351.848

存储条件：N/A℃

类别：Standards; Enzyme Activators and Inhibitors;

应用：N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.

参考文献：Jitkaew, S. et al. J. Bio. Chem., 284, 27827 (2009); Kim, K. et al. Biochem. Biophys. Res. Comm., 306, 954 (2003); Griscavage, J. et al. Biochem. Biophys. Res. Comm., 215, 721 (1995) 展开

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