芒柄花素

别名

7-羟基-3-（4-甲氧基苯基）-4-H-1-苯并吡喃-4-酮,7-羟基-3-（4-甲氧基苯基）色酮,7-羟基-4′-甲氧基异黄酮,刺芒柄花素,刺芒柄花醇,大豆苷元-4′-甲基醚,鹰嘴豆素B

一般描述

Formononetin is an O-methylated isoflavone, a phytoestrogen. It can be found in many legumes, different species of clovers primarily in Trifolium pratense L. (red clovers), and one of the main flavonoids found in Astragalus membranaceus (Huangqi).

应用

Formononetin has been used:
as a reference standard to study export of multiple metabolites from Crocus sativus stigma extracts using liquid chromatography-photodiode array-high resolution mass spectrometry (LC-PDA-HRMS)as phytoestrogen-mimetic isoflavones to test its antioxidant effects in a biomimetic environment using chemiluminescence methodas an authentic standard to test the isoflavones content level in both wild type and transgenic Medicago truncatula plant using high-performance liquid chromatography (HPLC)to test its effects as a potential Aryl hydrocarbon receptor (AhR)-agonist on the restoration of skin barrier proteins for Atopic dermatitis (AD) treatment using different keratinocyte cell lines and human skin equivalent (HSE) model

生化/生理作用

异黄酮在红三叶草中发现。可通过（至少部分通过）诱导肠粘膜中滋养体的分离，有效对抗 贾第鞭毛虫 的感染。 Formononetin elicits antioxidant, anti-inflammatory, anti-hyperlipidemic, and cardioprotective effects. It displays antidiabetic properties known to be effective against diabetic nephropathy in type 2 diabetes mellitus. Formononetin is a well-known anti-cancer and chemotherapeutic agent that is used in cancer therapy. It also displays antimicrobial, neuroprotective, and anti-hypertensive properties.