W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem

别名

N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride,W13

生化/生理作用

W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells. W-13 is a membrane-permeable calmodulin antagonist. W-13 inhibits Ca2+-calmodulin-dependent phosphodiesterase and has been shown to inhibit the EGF-dependent activation of EGFR in N7xHERc fibroblasts.