SR 48692

别名

2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid,Meclinertant

应用

SR 48692 has been used as a neurotensin high-affinity receptor 1 (NTSR1) antagonist:
to explore the function of NTSR1 in glioblastoma (GBM) cells to determine the roles of neurotensin (NT) in the regulation of bile acid (BA) uptake, in vivo to explore the involvement of NTSR1 versus NTSR2 in mice

生化/生理作用

SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.

特点和优势

This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.