CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem

别名

CXCR2 antagonist, Cpd 19 - CAS 473728-67-5 - Calbiochem,3-(2-(cyclopentylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide

一般描述

A cell-permeable, cyclobutenedione derivative that acts as a potent antagonist of chemokine receptor CXCR2 (IL8RB) (IC50 = 8 nM). Reported to inhibit CXCR2-mediated chemotaxis in a CXCR2 expressing cell line (IC50 = 145 nM). Exhibits good stability in human and rat liver microsomal preparations (>50% remaining after 30 min at 37°C).

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Merritt, J., et al. 2006. Bioorg. Med. Chem. Lett.16, 4107.