(?)-N6-(2-Phenylisopropyl)adenosine

别名

(R)-N⁶-(1-Methyl-2-phenylethyl)adenosine,N⁶-(L-2-Phenylisopropyl)adenosine,R-(−)-PIA

效能

1.17 nM Ki for A1 receptors (using [3H]CHA in rat forebrain preparations)

溶解性

H2O: slightly soluble 0.3 mg/mL (Solutions may be stored for several days at 4°C.)
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.6 mg/mL (Solutions may be stored for several days at 4°C.)

生化/生理作用

A1 adenosine receptor agonist. Affinity for adenosine receptor is approx. 100× that of the (+)-isomer.

特点和优势

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.