(R)-(+)-8-Hydroxy-DPAT hydrobromide

别名

(R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide,(R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide

应用

(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:
in mice to test the activity of the serotonin receptorto test its effect on zebrafish melanocyte migration and survival to stimulate hippocampal neurons

生化/生理作用

(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation. (R)-(+)-8-Hydroxy-DPAT is a full 5-HT1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.