JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

别名

JNK Inhibitor V - CAS 345987-15-7 - Calbiochem,SAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

一般描述

A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.

生化/生理作用

Cell permeable: yes Primary Target
hJNK 1, hJNK 2, hJNK 3 Product competes with ATP. Reversible: yes Target IC50: 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Gaillard, P., et al. 2005. J. Med. Chem.48, 4596.
Carboni, S., et al. 2005. J. Neurochem.92, 1054.
Ferrandi, C., et al. 2004. Br. J. Pharmacol.142, 953.
Carboni, S., et al. 2004. J. Pharm. Exp. Ther.310, 25. Soluble in DMSO, aliquot & store at -20*C; stable for 3 months