4-palmitamido-TEMPO

别名

4-Palmitamido-2,2,6,6-tetramethylpiperidine-1-oxyl; 2,2,6,6-Tetramethyl-4-[(1-oxohexadecyl)amino]-1-piperidinyloxy; 2,2,6,6-tetramethyl-4-palmitamidopiperidinooxy; 2,2,6,6-Tetramethylpalmitoylamidopiperidine-1-oxyl; 4-(Palmitylimino)-2,2,6,6-tetramethyl-1

一般描述

4-palmitamido-TEMPO/N-tempoyl-palmitamide is a spin label, that is present in the polar head-group region of the membrane. This amphiphilic compound binds strongly to membranes by virture of its long hydrocarbon chain, but the polarity of the amide linkage is expected to localize the nitroxide function in the aqueous phase adjacent to the membrane surface. The location of the nitroxide function allows one to investigate electrostatic potentials and lipid-protein interactions at the membrane surface.

应用

4-palmitamido-TEMPO/N-tempoyl palmitamide (N-TP) may be used:
to enrich rod outer segment (ROS) membranesas a spin probe in vesicles/bilayer to prepare samples for electron spin resonance (ESR) experimentsas a component in liposomes to assess the mobility of lipid headgroups