二异丙胺

效能

420 mg/kg LD50, oral (Rat)
2900 mg/kg LD50, skin (Rabbit)

一般描述

Diisopropylamine (DIPA) is an aliphatic secondary amine commonly used as an organic base in chemical synthesis.

应用

Diisopropylamine can be used as:

A reagent to synthesize furan, dihydrofuran, or butanolide derivatives by reacting with γ-ketothioesters. A catalyst to prepare aryl disulfides via oxidative coupling of aryl thiols in the presence of air as an oxidant. A base in Pd-catalyzed cross-coupling reactions such as Heck and Sonogashira reaction.
It can also be used as a starting material to prepare lithium diisopropylamide (LDA), a strong non-nucleophilic base widely used in organic synthesis for deprotonation reactions.