CGP-37157

别名

CGP-37157 - CAS 75450-34-9 - Calbiochem,7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

一般描述

A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.

生化/生理作用

Cell permeable: yes Primary Target
Mitochondrial Na+/Ca2+ exchanger Product does not compete with ATP. Reversible: no Target IC50: 360 nM against mitochondrial Na+/Ca2+ exchanger

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Jornot, L., et al. 1999. J. Cell Sci.112, 1013.
Babcock, D.F., et al. 1997. J. Cell Biol.136, 833.
Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol.340, 295.
Griffiths, E.J., et al. 1997. Cell Calcium21, 321.
White, R.J., and Reynolds, I.J. 1996, J. Neurosci.16, 5688.
Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol.21, 595.
Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem.268, 938.