BHQ - CAS 88-58-4 - Calbiochem

别名

BHQ - CAS 88-58-4 - Calbiochem,2,5-Di-( t-butyl)-1,4-hydroquinone, t-BuBHQ,2,5-Di-(t-butyl)-1,4-hydroquinone, t-BuBHQ

溶解性

DMSO: 1?mM
ethanol: 25?mg/mL
methanol: soluble

一般描述

Mobilizes Ca2+ specifically from Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Inhibits prostaglandin E2 and prostacyclin formation in osteoblast-like cell lines. Mobilizes Ca2+ specifically from the Ins(1,4,5)P3-sensitive Ca2+ stores by inhibiting microsomal and sarcoplasmic reticulum Ca2+-ATPase activity. Does not affect mitochondrial Ca2+ fluxes or plasma membrane Ca2+/Mg2+ ATPase activity. Useful for the study of endomembrane Ca2+ stores and plasma membrane Ca2+ permeability pathways.

生化/生理作用

Cell permeable: no Primary Target
micosomal and sarcoplasmic reticulation Ca2+ ATPase activity Product does not compete with ATP. Reversible: no

其他说明

Salvador, J.M., and Mata, A.M. 1998. Arch. Biochem. Biophys. 351, 272.
Leis, H.J., et al. 1996. Br. J. Pharmacol. 117, 540.
Khan, Y.M., et al. 1995. Biochemistry 34, 14385.
Hassessian, H., et al. 1994. Br. J. Pharmacol. 112, 1118.
Khodorova, A.B., and Astashkin, E.I. 1994. FEBS Lett. 353, 167.
Schilling, W.P., et al. 1992. Biochem. J.284, 521.
Wictome, M., et al. 1992. FEBS Lett.304, 109.
Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856.
Kass, G.N., et al. 1989. J. Biol. Chem.264, 15192.