CASIN

应用

CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:
to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cellsto study its effects on mice jejunumto study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice

生化/生理作用

CASIN是Cdc42 GTPase的抑制剂，Cdc42 GTPase是Rho亚家族的一种小GTP酶，在细胞骨架组织、细胞周期进程、信号转导和囊泡运输中起重要作用。 CASIN产生了造血干细胞（HSC）的恢复活力的表型，将衰老的HSC的衰老相关和极性表型逆转为体内年轻的HSC 的衰老相关和极性表型。