(±)-6-Chloro-PB hydrobromide

别名

(±)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide,(±)-SKF-81297 hydrobromide

溶解性

H2O: 1.7?mg/mL
DMSO: >10?mg/mL
ethanol: 6.3?mg/mL

应用

(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal?regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.

生化/生理作用

(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.