您好！欢迎来到 ChemDig
登录
注册
发布供应信息
我的ChemDig
供应商中心
网站导航
中文
中文
Chemdig
化工材料平台
商品
搜索
热搜 :
阿维菌素
首页
>
供应商
>
12-O-十四烷酰佛波醋酸酯-13
12-O-十四烷酰佛波醋酸酯-13
|
英文名称
|
12-O-tetradecanoylphorbol-13-acetate
|
|
CAS号
|
16561-29-8
|
|
分子量
|
617
|
|
中文别名
|
12-O-十四烷酰佛波醋酸酯-13
|
|
英文别名
|
12-O-tetradecanoylphorbol-13-acetate
|
属性
|
熔点
|
65-79oC
|
|
折射率
|
1.4900 (estimate)
|
|
溶解度
|
DMSO: DMSO solutions can be stored dark at −20°C for at least six months.soluble
|
|
形态
|
Fine Crystalline Powder
|
|
酸度系数(pKa)
|
11.19±0.70(Predicted)
|
|
颜色
|
Off-white to light yellow
|
|
水溶解性
|
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
|
|
BRN
|
2407201
|
|
EPA化学物质信息
|
安全
危险品标志
安全说明
危险品运输编号
2928
F
海关编码
29153900
毒性
Diesters of
phorbol, particularly 12-O-tetradecanoylphorbol 13-acetate, also
known as phorbol myristate acetate, have been identified as the
potent, highly lipophilic tumor-promoting components in croton
oil. They are potent promoters of skin tumors in vivo and have
been shown to transform cultured fibroblasts and embryonic cells
previously exposed to polycyclic aromatic hydrocarbon carcinogens in vitro. The structure of phorbol, the parent alcohol is
shown below. Phorbol esters also have important effects on leukocytes and on the immune system of the intact animal. There
appears to be a specific receptor for phorbol esters on T cells, a
finding that may account for the selective toxicity of phorbol
esters for T cells. The mechanism of tumor promotion by phorbol
esters is still largely unknown, but findings suggest an initial cell
membrane interaction (often with stimulation of second messenger synthesis and increased protein kinase activity), with subsequent effects on nuclear regulatory events.
|
|
|
联系电话:
|
400-666-7788;86-10-82849933
|
|
公司网址:
|
|
|
|||||||||
|
|
|
联系电话:
|
18616739031
|
|
公司网址:
|
|
|
|||||||||
|
|
|
联系电话:
|
18521732826
|
|
公司网址:
|
|
|
|
|
|
联系电话:
|
|
|
公司网址:
|
|
|
|
|
|
联系电话:
|
|
|
公司网址:
|
|
|
|
|
|
联系电话:
|
18621169109
|
|
公司网址:
|
|
|
|
|
|
联系电话:
|
800-8193336
|
|
公司网址:
|
|
|
|||||||||
|
|
|
联系电话:
|
021-58432009
|
|
公司网址:
|
|
|
|
|
|
联系电话:
|
18019345275
|
|
公司网址:
|
|
|
|
|
|
联系电话:
|
18548936886;010-62340519
|
|
公司网址:
|
|
|
|
|
|
联系电话:
|
15386497078
|
|
公司网址:
|
|
|
|
|
|
联系电话:
|
|
|
公司网址:
|
|
|
|
|
|
|
联系电话:
|
|
|
公司网址:
|
|
|
上一页
1
下一页
到
页
确 定
|
公众号 |
置顶
