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吡啶-2,3-二羧酸
吡啶-2,3-二羧酸
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英文名称
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Quinolinic acid
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CAS号
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89-00-9
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分子量
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167
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中文别名
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吡啶-2,3-二羧酸
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英文别名
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Quinolinic acid
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属性
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折射率
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1.6280 (estimate)
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溶解度
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10g/l
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形态
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Crystalline Powder
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酸度系数(pKa)
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2.43(at 25℃)
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颜色
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White to light yellow-beige
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气味 (Odor)
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odorless
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水溶解性
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0.55 g/100 mL
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BRN
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137110
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EPA化学物质信息
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安全
危险品标志
安全说明
海关编码
29333999
毒性
Focal injection of quinolinic acid
into specific areas of the brain produces neuronal damage
although sparing axons of passage. Similarities between the
biochemical and morphological profiles of these lesions and
human neuropathy seen in neurodegenerative diseases have led
to the proposal that endogenous excitotoxins may play a role
in such neurodegenerative disease states. Quinolinic acid is an
intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals
including man. The neuroexcitatory action is thought to be
mediated via interaction with the N-methyl-D-aspartate
(NMDA) receptor of the glutamate family. No mechanism for
quinolinic acid removal, nor for synaptic inactivation, has been
found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur.
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联系电话:
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400-164-7117;021-61629020-8031;15221909166
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公司网址:
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联系电话:
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400-666-7788;86-10-82849933
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联系电话:
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18616739031
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联系电话:
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18521732826
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联系电话:
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18621169109
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联系电话:
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800-8193336
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联系电话:
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021-58432009
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联系电话:
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18019345275
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联系电话:
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18548936886;010-62340519
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