渥曼青霉素

中文名称：渥曼青霉素

英文名称： WORTMANNIN

CAS： 19545-26-7

分子式： C₂₃H₂₄O₈

分子量： 428

EINECS号： 606-337-5

中文同义词渥曼青霉素英文同义词

WORTMANNIN

基本性质

比旋光度	+80.0～+105.0゜(20℃/D)(c=0.1,C2H5OH)
折射率	1.4480 (estimate)
溶解度	DMSO: soluble
形态	powder
颜色	off-white
最大波长(λmax)	296nm(lit.)
BRN	67676

安全信息

危险品标志	T+,T,Xi,Xn,F
安全说明	28-36/37-45-37/39-26-16
危险品运输编号	UN 3462 6.1/PG 1
F	3-8-10
危险性描述	H300+H310+H330
海关编码	29322090

CHS信息

危险性符号(GHS)	GHS06
防范说明	P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310

生产方法及用途

用途	一种PI3Ks和PLK1的特异性共价抑制剂。Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii, is a specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K.

用途

一种PI3Ks和PLK1的特异性共价抑制剂。Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii, is a specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K.