T0070907

中文名称： T0070907

英文名称： T0070907

CAS： 313516-66-4

分子式： C₁₂H₈ClN₃O₃

分子量： 278

EINECS号：

中文同义词英文同义词

T0070907

基本性质

熔点	>184°C (dec.)
溶解度	DMSO: >10mg/mL
形态	White solid
颜色	white
水溶解性	Soluble in DMSO at 10mg/ml. Insoluble in water.

安全信息

危险品标志	Xn
危险类别码	22-36
安全说明	26
海关编码	29333990

CHS信息

危险性符号(GHS)	GHS07

生产方法及用途

用途	A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPAR γ over PPARα and PPARδ (Ki = 0.85 μM and 1.8 μM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived pepti des, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding dom ain.

用途

A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPAR γ over PPARα and PPARδ (Ki = 0.85 μM and 1.8 μM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived pepti des, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding dom ain.