4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮

中文名称： 4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮

英文名称： TDZD-8

CAS： 327036-89-5

分子式： C₁₀H₁₀N₂O₂S

分子量： 222

EINECS号：

中文同义词 4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮英文同义词

TDZD-8

基本性质

沸点	335.5±35.0 °C(Predicted)
密度	1.375±0.06 g/cm3(Predicted)
溶解度	DMSO: 18 mg/mL
形态	needles
酸度系数(pKa)	-2.08±0.20(Predicted)
颜色	white

安全信息

危险品标志	Xi
危险类别码	43
安全说明	36/37
危险性描述	H334
海关编码	2934999090

CHS信息

危险性符号(GHS)	GHS08
防范说明	P261-P342+P311

生产方法及用途

用途	Glycogen Synthase Kinase-3β is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazo lidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β ( IC50 =2nM). Binds to the active site of GSK-3β. Does not significantly affect the activities of Cd k-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).

用途

Glycogen Synthase Kinase-3β is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazo lidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β ( IC50 =2nM). Binds to the active site of GSK-3β. Does not significantly affect the activities of Cd k-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).