SB 216763

中文名称： SB 216763

英文名称： SB216763

CAS： 280744-09-4

分子式： C₁₉H₁₂Cl₂N₂O₂

分子量： 371

EINECS号：

中文同义词英文同义词

SB216763

基本性质

溶解度	DMSO: 20 mg/mL, soluble
形态	Orange solid
酸度系数(pKa)	7.27±0.60(Predicted)
颜色	orange

安全信息

危险品标志	Xi
安全说明	26-36
海关编码	29339900

CHS信息

危险性符号(GHS)	GHS07

生产方法及用途

用途	一种有效、选择性和ATP竞争性的GSK-3抑制剂，抑制GSK-3α和GSK-3β的 IC50为34.3nM。SB-216763 is a glycogen synthase kinase-3 (GSK3) inhibitor, which can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). SB-216763 is the first GSK3 inhibitor that can promote self-renewal of mESC co-cultured with MEFs for more than two months.

用途

一种有效、选择性和ATP竞争性的GSK-3抑制剂，抑制GSK-3α和GSK-3β的 IC50为34.3nM。SB-216763 is a glycogen synthase kinase-3 (GSK3) inhibitor, which can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). SB-216763 is the first GSK3 inhibitor that can promote self-renewal of mESC co-cultured with MEFs for more than two months.