匹利诺生

中文名称：匹利诺生

英文名称： IB-MECA

CAS： 152918-18-8

分子式： C₁₈H₁₉IN₆O₄

分子量： 510

EINECS号：

中文同义词匹利诺生英文同义词

IB-MECA

基本性质

溶解度	hot ethanol: >10 mg/mL
形态	solid
酸度系数(pKa)	12.72±0.70(Predicted)
颜色	white

安全信息

安全说明	22-24/25
WGK Germany	3

CHS信息

生产方法及用途

用途	一种腺苷A3受体激动剂, EC50值为0.11μM。Piclidenoson is a specific agonist to the A3 adenosine receptor, which inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. CF101 has been shown to downregulate PKB/Akt and NF-κB protein expression level. CF101 potentiates the cytotoxic effect of 5-FU, thus preventing drug resistance. The myeloprotective effect of CF101 suggests its development as an add-on treatment to 5-FU.

用途

一种腺苷A3受体激动剂, EC50值为0.11μM。Piclidenoson is a specific agonist to the A3 adenosine receptor, which inhibits the development of colon carcinoma growth in cell cultures and xenograft murine models. CF101 has been shown to downregulate PKB/Akt and NF-κB protein expression level. CF101 potentiates the cytotoxic effect of 5-FU, thus preventing drug resistance. The myeloprotective effect of CF101 suggests its development as an add-on treatment to 5-FU.