SC-514

中文名称： SC-514

英文名称： SC-514

CAS： 354812-17-2

分子式： C₉H₈N₂OS₂

分子量： 224

EINECS号：

中文同义词英文同义词

SC-514

基本性质

溶解度	DMSO: soluble10mg/mL, clear
形态	powder
酸度系数(pKa)	15.63±0.50(Predicted)
颜色	white to light brown

安全信息

危险品标志	T
危险类别码	25
安全说明	45

CHS信息

危险性符号(GHS)	GHS07

生产方法及用途

用途	A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.

用途

A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.